Marijuana Study Finds CBD Can Cause Liver Damage


2019-06-19 13:07:00 Forbes


Hemp oil, Hand holding bottle of Cannabis oil against Marijuana plant, CBD oil pipette. alternative remedy or medication,medicine concept Since then, CBD, a substance often touted as being safer than popping pills, has risen to infamy as an alternative treatment for a variety of common ailments from anxiety to chronic pain. But a new study suggests that CBD may spawn its fair share of health issues. Specifically, scientists have learned that this substance could be damaging our livers in the same way as alcohol and other drugs.  Researchers at the University of Arkansas for Medical Science recently rolled up their sleeves to investigate CBD hepatotoxicity in mice. What they found was while this cannabis derivative is gaining significant recognition as of late in the world of wellness, people that use CBD are at an elevated risk for liver toxicity. The findings, which were published earlier this year in the journal Molecules, suggest that while people may be using CBD as a safer alternative to conventional pain relievers, like acetaminophen, the compound may actually be just as harmful to their livers.  It is the methods used in this study that makes it most interesting. First, researchers utilized all of the dosage and safety recommendations from a CBD-based drug known as Epidiolex. If this name sounds familiar, it should. Last year, the U.S. Food and Drug Administration approved it as a treatment for certain kinds of childhood epilepsy. It was a development that marked the first time in history that a cannabis-based medicine was approved for nationwide distribution in the United States.  Researchers then spent some time examining mice under the influence of various doses of CBD. Some of the animals received lower doses, while others were given more. The dosage is said to have been "the allometrically scaled mouse equivalent doses (MED) of the maximum recommended human maintenance dose of CBD in EPIDIOLEX (20 mg/kg)."  Shockingly, researchers discovered that the mice given higher doses of CBD showed signs of liver damage within 24 hours. To that end, 75 percent of these animals in the sub-acute phase had either died or were on the verge of death within a few days.  Regardless of your feelings on this particular study, it is hard to argue with dead mice – even if you are an all-knowing marijuana expert.  Liver toxicity is an adverse reaction to various substances. Alcohol, drugs and even some natural supplements can all take their toll on liver function – even in healthy individuals. But this is the first study of its kind indicating that CBD might be just as detrimental to the human liver as other chemicals.  But come to find out, there has been evidence of CBD's havoc wreaking ways on the liver for some time.  Lead study author Igor Koturbash, PhD, recently told the health site Nutra Ingredients USA that the risk of liver damage from CBD is a nasty side effect printed in black and white on GW Pharma's Epidiolex packaging.  "If you look at the Epidolex label," he said, "it clearly states a warning for liver injury. It states you have to monitor the liver enzyme levels of the patients. In clinical trials, 5% to 20% of the patients developed elevated liver enzymes and some patients were withdrawn from the trials," he added.  In other words, anyone taking CBD regularly and in higher doses might unwittingly find themselves on the road to liver disease.  Previous studies have also suggested that certain components of the cannabis plant may be harmful to the liver. Although one study found that marijuana may actually help prevent liver damage in people with alcoholism, in some cases it worsened the condition. “Patients with hepatitis C who used cannabis had way more liver scarring than those who didn’t and more progression of their liver disease. Something in the cannabis could actually be increasing fatty liver disease,” Dr. Hardeep Singh, gastroenterologist at St. Joseph Hospital in Orange, California, told Healthline.  But wait, it gets worse. The latest study also finds that CBD has the potential for herbal and drug interactions. "CBD differentially regulated more than 50 genes, many of which were linked to oxidative stress responses, lipid metabolism pathways and drug metabolizing enzymes," the study reads. However, Dr. Koturbash was quick to point out that the CBD products coming to market may not pose this particular risk. What he is sure of, however, is that more research is needed on CBD to evaluate its overall safety. As it stands, none of the CBD products being sold in grocery stores and malls all over the nation have received FDA approval. And the only CBD-based medicine that has been approved, Epidiolex, is apparently stamped with a big, fat warning of potential liver damage.  Sounds like we might as well be medicating with vodka, folks! Just tell the bartender to hold the bonus shot of CBD. 
大麻油,手持大麻药瓶对大麻植物, CBD 石油管道。替代疗法或药物,医学概念 从那时起, CBD ,一种通常被认为比起起泡药丸更安全的药物,已经成为一种替代治疗多种常见疾病的方法,从焦虑到慢性疼痛。但一项新的研究表明,生物多样性公约可能产生其公平份额的健康问题。特别是,科学家已经了解到这种物质可能会像酒精和其他药物一样损害我们的肝脏。 阿肯色医学科学大学的研究人员最近对小鼠的 CBD 肝毒性进行了研究。他们发现,当这种大麻衍生物在健康世界晚期得到显著认可时,使用 CBD 的人对肝脏毒性的风险较高。 今年早些时候发表在《分子》杂志上的这一发现表明,尽管人们可能使用 CBD 作为传统止痛药物的一种更安全的替代品,比如对乙酰氨基酚,但这种化合物实际上可能对他们的肝脏同样有害。 本研究采用的方法使之最有趣。 首先,研究人员利用了 CBD 药物 Epdiolex 的所有剂量和安全性建议。如果这个名字听起来很熟悉,它应该。去年,美国食品药品监督管理局(Food and Drug Administration)批准它作为一种治疗儿童癫痫的药物。这是历史上第一次批准在美国全国范围内销售以大麻为基础的药品。 研究人员在不同剂量 CBD 的影响下花了一段时间研究老鼠。有些动物的剂量较低,而另一些动物的剂量较多。该剂量据说是“在 EPIDIOLEX (20毫克/千克)中,异体比例小鼠当量剂量( MED )的最大推荐人体维持剂量 CBD ”。这是一个很好的例子 令人震惊的是,研究人员发现,服用较高剂量 CBD 的老鼠在24小时内出现肝损伤的迹象。为此,这些处于亚急性阶段的动物中有75%在几天内死亡或濒临死亡。 不管你对这一特殊研究有什么感觉,都很难与死鼠争论——即使你是一位全知的大麻专家。 肝脏毒性是对各种物质的不良反应.酒精、药物甚至一些天然补充剂都会影响肝脏功能——即使是健康的个体也是如此。但这是首次进行此类研究,表明 CBD 可能与其他化学物质一样对人类肝脏有害。 但要知道,有证据表明 CBD 在一段时间内对肝脏造成了严重破坏。 主要研究作者 Igor Koturash 博士最近告诉健康网站 Nutra Ingredients USA , CBD 的肝脏损害风险是印刷在 GW 制药的 Epidepollex 包装的黑色和白色的副作用。 “如果你看看 Epidlex 的标签,”他说,“它清楚地说明了肝损伤的警告。它说你必须监测病人的肝酶水平。在临床试验中,5%到20%的患者出现肝酶升高,一些患者退出试验,”他补充说。 换句话说,任何经常服用 CBD 且剂量较高的人都可能不知不觉地发现自己正处在肝病的道路上。 先前的研究也表明大麻植物的某些成分可能对肝脏有害。尽管一项研究发现,大麻实际上有助于预防酒精症患者的肝脏损害,但在某些情况下,大麻会使病情恶化。 “使用大麻的丙肝患者比没有使用大麻的患者有更多的肝脏瘢痕。大麻中的某些物质实际上可能会增加脂肪肝疾病,”圣乔治医院的胃肠病学家哈迪普·辛格博士说。加利福尼亚州奥兰治市的约瑟夫医院告诉 Healthline 。 但等着,情况就更糟了。 最新的研究还发现,生物多样性公约具有潜在的草药和药物相互作用。“ CBD 差异调节了50多个基因,其中许多与氧化应激反应、脂质代谢途径和药物代谢酶有关,”该研究指出。 然而, Koturash 博士很快指出,进入市场的 CBD 产品可能不会构成这种特殊风险。然而,他确信 CBD 需要更多的研究来评估它的整体安全性。 目前,在全国各地的杂货店和商场销售的 CBD 产品都没有获得 FDA 的批准。而唯一获得批准的基于 CBD 的药物, Epidelex ,显然是贴上了一个大的,脂肪的潜在肝损害警告。 听起来我们也可以用伏特加给药,伙计!只要告诉酒保拿 CBD 的奖金.