New research effort builds upon landmark study with CDC and will provide additional insights on the most promising interventions and emerging innovations in addressing adverse childhood experiences
Kaiser Permanente, the nation's largest nonprofit, integrated health system, announced today that it will allocate $2.75 million in new research led by Kaiser Permanente research scientists to help prevent and mitigate the health effects of adverse childhood experiences, known as ACEs. This research funding is part of Kaiser Permanente's long-term commitment to improving the total health of its members and the communities it serves.
ACEs are defined as traumatic childhood events that occur before the age of 18 across multiple categories, including abuse, neglect, household dysfunction, systemic racism, and living in a high-crime neighborhood. Experiencing multiple ACEs can be associated with a long-lasting exaggerated stress response that has been linked to risky health behaviors and chronic health conditions. Previous studies have indicated that those with 4 or more ACEs are 12 times more likely to attempt suicide, and those with 6 or more ACEs have a 20-year shorter life expectancy.
"We believe every child deserves a healthy start to their physical and mental health," said Bernard J. Tyson, chairman and CEO, Kaiser Permanente. "Our landmark research on ACEs brought new understanding to the long-term impacts of childhood trauma, and we are now expanding our work with the bold ambition to prevent and minimize ACEs — and create healthier and more resilient generations in the future."
The intention for the new research funding is to provide important insights for both clinical and community-based interventions to help address ACEs. As part of this work, Kaiser Permanente is currently conducting a systematic review of existing research on ACEs to help identify gaps in current knowledge as well as successful programs, emerging best practices, and interventions in the field that may be ready to be scaled. The completed review will guide the formation of the research program, and target the investments in new research to the areas where they will have the greatest impact.
"Our goal is to provide additional insights on the most promising interventions and emerging innovations, while continuing to build the evidence base for the case that we can break inter-generational cycles of childhood trauma and create a brighter future for children," said Don Mordecai, MD, Kaiser Permanente's national leader for mental health and wellness. "We hope that this new research funding will also have a catalytic impact in the field, attracting new partners and other organizations to advance research and programs in this area as well."
Currently, Kaiser Permanente expects to issue requests for proposals to Kaiser Permanente research groups for ACEs-related research next year. Some initial areas of focus for the research may include:
Identifying important protective factors in the prevention of ACEs
Mitigating the negative effects of ACEs for a child throughout the course of his or her life
Identifying the most effective or promising combinations of community-based services that can successfully address ACEs
Kaiser Permanente was one of the first health care organizations to recognize the link between trauma and health through the ACEs study that it conducted along with the U.S. Centers for Disease Control and Prevention. The study, released in 1998, was one of the largest investigations of its kind and illuminated the connection between childhood trauma, stress, and maltreatment with health and well-being later in life. Since then, work toward studying and addressing the impacts of ACEs has continued to increase. This year, Nadine Burke Harris, MD, pediatrician, researcher, and California's first surgeon general, said one of her top priorities is to raise awareness that ACEs can increase the risk of major health problems.
"ACEs are a root cause of many of the greatest public health challenges we face today — increasing the risk of serious conditions ranging from heart disease, chronic lung disease, and suicide, to gun violence, domestic violence, and substance dependence," said Dr. Burke Harris. "The science has given us insights to identify childhood adversity as an important health risk. With additional rigorous research, we have a great opportunity to continue to create breakthrough improvements in the health and well-being of our communities to advance prevention of ACEs and treatment of toxic stress."
About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America's leading health care providers and not-for-profit health plans. Founded in 1945, Kaiser Permanente has a mission to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve 12.3 million members in eight states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal Permanente Medical Group physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the-art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health. https://about.kaiserpermanente.org/
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全国最大的非营利综合卫生系统 Kaiser Permanente 今天宣布，它将拨款275万美元用于由 Kaiser Permanente 研究科学家领导的新研究，以帮助预防和减轻儿童不良体验（即 ACE ）对健康的影响。这项研究经费是凯撒·佩雷曼恩特长期致力于改善其成员及其服务的社区的总健康状况的一部分。
ACE 被定义为创伤童年事件，发生在18岁之前，跨越多个类别，包括虐待，忽视，家庭功能障碍，系统性种族主义，生活在一个高犯罪的社区。经历多重 ACE 可能与长期的夸大压力反应有关，这与危险的健康行为和慢性健康状况。先前的研究表明，拥有4个或更多 ACE 的人自杀的可能性是12倍，拥有6个或更多 ACE 的人的预期寿命缩短了20年。
Kaiser Permanente 董事长兼首席执行官 Bernard J . Tyson 说：“我们相信每个孩子都应该健康地开始他们的身体和精神健康。”“我们对 ACE 的里程碑式的研究为儿童创伤的长期影响带来了新的认识，我们现在正在扩大我们的工作，以大胆的雄心来预防和减少 ACE ，并创造更健康和更有弹性的后代在未来。”
新研究基金的目的是为临床和社区干预提供重要的见解，以帮助解决 ACE 问题。作为这项工作的一部分， Kaiser Permanente 目前正在对 ACE 的现有研究进行系统的审查，以帮助确定当前知识的差距以及成功的项目、新出现的最佳做法和可能准备扩大的领域的干预措施。完成的审查将指导研究计划的形成，并将新研究的投资目标锁定在它们将产生最大影响的领域。
“我们的目标是提供更多关于最有希望的干预措施和新出现的创新的见解，同时继续为我们能够打破儿童创伤代际循环并为儿童创造更光明的未来的案例奠定证据基础，” Don Mordecdi 医学博士说，Kaiser Permanente 的精神健康和健康国家领导人。“我们希望这一新的研究资金也将对该领域产生催化作用，吸引新的合作伙伴和其他组织来推进该领域的研究和项目。”
目前， Kaiser Permanente 预计明年将向 Kaiser Permanente ACE 相关研究小组发出征求建议书的请求。研究的一些初步重点领域可能包括：
确定预防 ACE 的重要保护因素
在孩子一生中减轻 ACE 的负面影响
确定能够成功解决 ACE 的基于社区的服务的最有效或最有希望的组合
Kaiser Permanente 是第一个通过 ACE 研究认识创伤与健康之间联系的卫生保健组织，该研究与美国疾病控制和预防中心一起进行。该研究于1998年发表，是同类研究中规模最大的一项，揭示了儿童创伤、压力、虐待与后期健康和幸福之间的关系。此后，研究和处理 ACE 影响的工作继续增加。今年， Nadine Burke Harris 医学博士、儿科医生、研究人员和加州第一位外科医生说，她的首要任务之一是提高人们对 ACE 可能增加重大健康问题风险的认识。
“ ACE 是我们今天面临的许多最大的公共卫生挑战的根本原因——增加了严重疾病的风险，包括心脏病、慢性肺病、自杀、枪支暴力、家庭暴力和物质依赖，”伯克哈里斯博士说。“科学给我们提供了洞察，以确定儿童的逆境是一个重要的健康风险。通过进一步的严格研究，我们有很大的机会继续在我们社区的健康和福利方面取得突破性进展，以促进 ACE 的预防和有毒压力的治疗。”
关于 Kaiser Permanente
Kaiser Permanente 致力于帮助塑造未来的医疗保健。我们被公认为美国领先的医疗保健提供者和非营利医疗计划。凯泽 Permanente 成立于1945年，其使命是提供高质量、负担得起的医疗保健服务，改善我们成员和我们服务的社区的健康。我们目前服务于8个州和哥伦比亚特区的1230万会员。对会员和患者的护理集中在他们的整体健康，并由他们的个人 Permanente 医疗组的医生、专家和护理人员团队指导。我们的专家和关怀医疗团队得到业界领先的技术进步和工具的支持，促进健康，预防疾病，提供最先进的护理和世界级的慢性病管理。凯泽 Permanente 致力于医疗创新、临床研究、健康教育和社区卫生的支持。