More and more pet owners are wondering how CBD oil for dogs might be able to help. When I met my partner, his family dog was elderly and suffering from osteoarthritis and dementia. She wandered around the property only half-sure of where she was. We put her on a dropper-full of CBD oil daily with her food and the results were immense. The formerly crotchety dog would spend her mornings romping around with the puppies before calmly napping her afternoon away.
These results are obvious but even so, people aren’t comfortable dosing their dogs without science-backed data. This is why lately veterinary researchers are focusing on the results and side effects of supplementary CBD oil for dogs. At this time there are very few studies informing pet owners and vets about what CBD oil, capsules, or topical applications actually do for canines. On top of that, further research is needed into what dosages are appropriate and possible contraindications with other canine medications, to name just a few remaining considerations.
While there is not much solid research into CBD oil for dogs, there is quite a bit known about the compound itself. CBD is one of many cannabinoids found in the cannabis plant. The most commonly known cannabinoid is THC, but there are also hundreds of others including CBG, CBN, THCv, and more. Each of these cannabinoids interacts with receptors in our endocannabinoid system called labeled CB1 and CB2.
CBD only interacts with CB2 receptors, which are found in the body, and not with CB1 receptors, which are primarily found in the brain. This action is why inhaling or ingesting CBD doesn’t cause psychoactive, “high” effects. Instead, it interacts with the muscles, tissues, and other aspects of the body for mentally non-intrusive effects. That’s why the cannabinoid has been gaining so much popularity — in most cases, it won’t “get you high.” Consumers enjoy the ability to feel relief from stress and muscle tension without being debilitated by a psychoactive and potentially stressful experience.
As mentioned earlier, there aren’t many scientific studies available covering CBD oil for dogs, but there are a few. One study, which was approved by Colorado State University’s Institutional Animal Care and Use Committee, surveyed 30 male Beagle dogs around the same age and weight after being given CBD supplements of three kinds over a period of six weeks. Their goal was to identify any adverse reactions pets may experience when administered various modes of CBD supplements.
The beagles were split into three groups who were all given CBD twice daily through three different methods. Group 1 had transdermal cream rubbed on their inner ear, Group 2 received CBD capsules, and Group 3 was administered CBD oil orally. The dogs’ vitals, urinalysis, and stomach chemistry were recorded at 2, 4, and 6 weeks. Results showed that many of the dogs suffered minor diarrhea or vomiting, but a change in housing and having strange dogs around could have contributed to that. Another important observation during the study showed that 36% of dogs had a significant elevation in alkaline phosphatase enzyme (ALP) which can be an indicator of cholestatic liver disease. This side effect was only present in canines administered the oral CBD supplements, suggesting that too much CBD oil can be an issue for our furry friends.
Another study set out to understand the pharmacokinetics of CBD in dogs with Osteo Arthritis (OA). Twenty-two dogs were administered CBD or a placebo by their owners over a period of four weeks. At weeks 2 and 4 a baseline veterinary assessment and owner survey were completed for analysis purposes. Pups received 2 mg of CBD oil per kg of their weight every 12 hours. The conclusion showed that CBD-rich oils were a viable alternative to non-steroidal anti-inflammatory drugs. However, the oils were very expensive when applying the dosage necessary to relieve the pain of OA, making it a bit cost prohibitive despite efficacy.
The last study that we looked at also used Beagles of median age and weight, dosing them with 2mg per kg of weight every 12 hours over a period of 12 weeks. Every 4 weeks blood was drawn from each dog and sent to a lab for analyzation. This study concluded that ingestible oil is the most effective method of administration, which a glycerol/fiber/starch-based chew also showing less impressive retention and half-life as compared to pure CBD oil.
Their findings lead researchers in this study to speculate that CBD oil leads to better absorption and possible inclusion in a food matrix makes absorption even more effective. Most importantly, findings suggest that treating a dog for seizures requires 2.5mg/kg while treating a dog for OA requires just 2 mg/kg. No adverse reactions were noted, including the fact that no dogs showed heightened ALP levels like the first study discussed here leading to the conclusion that more research is needed to better understand a dog’s hepatic response to CBD.
Though the data in these studies varies, it does give dog owners somewhere to start. What all of these studies have in common is that no dogs suffered severe illness or issues along with the administration of CBD. Researchers all also seem to agree on a dose somewhere between 2-3mg/kg for canines. These research articles prove that taking CBD regularly can benefit dogs with OA or seizures, but it is necessary to pay extra attention to ALP levels.
越来越多的宠物主人想知道 CBD 给狗提供的油是如何帮助的。当我遇到我的伴侣时，他的家犬很老，患有骨关节炎和痴呆。她只在她住的地方闲逛了一半。我们每天给她的食物加满一滴 CBD 油，结果是巨大的。这条从前的弯腰狗会和小狗一起在早上闲逛，然后平静地午后睡着。
这些结果是显而易见的，但即便如此，如果没有科学数据的支持，人们也不会轻易给狗喂食。这就是为什么最近兽医研究人员关注的结果和补充 CBD 油对狗的副作用。在这个时候，很少有研究告诉宠物主人和兽医什么 CBD 油，胶囊，或局部应用实际为犬类。除此之外，还需要进一步研究什么剂量是适当的和可能的禁忌症与其他犬类药物，仅举几个剩下的考虑。
虽然对狗的 CBD 油没有太多可靠的研究，但是对这种化合物本身却有相当多的了解。CBD 是大麻植物中发现的许多大麻之一。最常见的大麻是 THC ，但也有数以百计的其他包括 CBG ， CBN ， THCv ，等等。这些大麻素中的每一个都与被称为 CB1和 CB2的内分泌系统中的受体相互作用。
CBD 只与身体中的 CB2受体相互作用，而不与主要在大脑中发现的 CB1受体相互作用。这就是为什么吸入或吸入 CBD 不会引起精神上的“高”效应的原因。相反，它与身体的肌肉、组织和其他方面相互作用，产生精神上的非侵入性影响。这就是为什么大麻已经变得如此流行——在大多数情况下，它不会“让你变得很高”。消费者可以在不受精神活跃和潜在压力的影响的情况下，从压力和肌肉紧张中感受到舒缓。
正如前面提到的，目前还没有很多关于狗用 CBD 油的科学研究，但是还有一些。一项由科罗拉多州立大学机构动物保护和使用委员会批准的研究对30只相同年龄和体重的雄性比格犬进行了调查，这些狗在六周内服用了三种 CBD 补充剂。他们的目标是确定任何不良反应宠物可能会遇到的时候，给予各种模式的 CBD 补充。
将海狸分成三组，通过三种不同的方法，每天给 CBD 两次。第1组内耳经皮霜擦伤，第2组接受 CBD 胶囊，第3组口服 CBD 油。在2周、4周和6周时记录了狗的生命、尿液分析和胃化学。结果显示，许多狗只有轻微腹泻或呕吐，但住房的改变和周围有奇怪的狗可能是造成这种情况的原因。另一项重要观察显示，36%的狗在碱性磷酸酶（ ALP ）中有显著升高，而碱性磷酸酶（ ALP ）可以作为胆汁性肝病的指标。这种副作用只存在于口服 CBD 补充剂的犬类中，这表明过量的 CBD 油可能是我们毛茸茸的朋友的问题。
另一项研究开始了解骨关节炎（ OA ）犬 CBD 的药代动力学。22只狗在四个星期的时间里被主人服用 CBD 或安慰剂。在第2周和第4周，为分析目的完成了兽医评估和业主调查。每12小时，小狗每公斤体重可获得2毫克的 CBD 油。结论表明，富含 CBD 的油是非甾体抗炎药的有效替代品。然而，当使用必要的剂量以减轻 OA 的疼痛时，这些油非常昂贵，尽管有疗效，它还是有些昂贵。
我们研究的最后一项研究也使用了中等年龄和体重的比格勒，在12周的时间里每12小时给他们注射2毫克每公斤体重。每4周从每只狗身上提取血液，送到实验室进行分析。本研究的结论是，食油是最有效的给药方法，与单纯 CBD 油相比，甘油/纤维/淀粉为基础的咀嚼也表现出较少的保留和半衰期。
他们的研究结果使研究人员推测 CBD 油可以更好地吸收，并且可能包含在食物基质中，使吸收更有效。最重要的是，研究结果表明，治疗癫痫需要2.5毫克/千克，而治疗 OA 的狗只需要2毫克/千克。没有发现不良反应，包括没有狗显示出像这里讨论的第一项研究那样的 ALP 水平升高，从而得出结论，需要更多的研究来更好地了解狗对 CBD 的肝脏反应。
尽管这些研究中的数据各不相同，但它确实给了狗的主人一个开始。所有这些研究的共同之处是，没有狗遭受严重疾病或问题与管理 CBD 。研究人员似乎都同意在2-3mg / kg 的剂量范围内使用犬药。这些研究文章证明，定期服用 CBD 可以使患有 OA 或癫痫的狗受益，但需要特别注意 ALP 水平。