New Cannabinoid Found With 30x the Potency of THC

新的大麻发现与30倍的毒性 THC

2020-01-04 00:40:10 Ganjapreneur

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Researchers at Italy’s University of Salento have discovered two new cannabinoids – THCP and CBDP – and THCP could be more potent than THC, according to an outline of the study by the Growth Op. In tests on mice, researchers found that THCP showed “an affinity for CB1 receptor more than thirty-fold higher compared to the one reported for THC.” “THCP is endowed of an even higher binding affinity for CB1 receptor and a greater cannabimimetic activity than THC itself.” –  “A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol,” Nature Research, 2019 The other compound – CBDP – reportedly doesn’t bind well to CB1 or CB2 receptors which doesn’t make the cannabinoid a priority for further research; however, the researchers said that THCP “should be included in the list of the main phytocannabinoids to be determined for a correct evaluation of the pharmacological effect of the cannabis extracts administered to patients.” According to the study, new research will continue to test how THCP cannabinoid acts as an antioxidant, anti-inflammatory and anti-epileptic activity – the health benefits most associated with CBD. The research brings the total number of discovered cannabinoids in the cannabis plant to 150, though the researchers note that “most of them have neither been isolated nor characterized.” The two new cannabinoids “were isolated and fully characterized” by researchers “and their absolute configuration was confirmed by a stereoselective synthesis.” The researchers suggest that “other varieties of cannabis may contain even higher percentages” of THCP.
意大利萨伦顿大学( University of Salento )的研究人员发现,根据 Growth Op 的研究大纲,两种新的大麻制剂—— THCP 和 CBDP ——可能比 THC 更有效。在小鼠的试验中,研究人员发现 THCP 显示“与 THC 相比, CB1受体的亲和力要高出30倍以上。” “ THCP 对 CB1受体具有更高的结合亲和力,比 THC 本身具有更大的大麻活性。”-“一种从大麻中分离出来的新型植物类二萜,其体内的大麻精活性高于Δ9-四氢大麻酚:Δ9-四氢大麻酚,” Nature Research ,2019年 另一种化合物—— CBDP ——据报道不能很好地与 CB1或 CB2受体结合,这并不能使大麻成为进一步研究的重点;然而,研究人员表示, THCP “应该被包括在主要植物类化合物的列表中,以确定对给患者服用的大麻提取物的药理作用的正确评估。” 根据这项研究,新的研究将继续测试 THCP 大麻作为一种抗氧化剂、抗炎和抗癫痫活性的作用——这是与 CBD 最相关的健康益处。 这项研究使大麻植物中发现的大麻总数达到150种,尽管研究人员指出“大多数大麻既没有被隔离,也没有被定性”。这两种新的大麻素“被研究人员分离并完全表征”,其绝对构型通过立体选择性合成得到证实。 研究人员建议,“其他种类的大麻可能含有更高的 THCP 百分比”。

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