Zinc, folic acid supplement does not improve male fertility, NIH study suggests

NIH研究表明:锌,叶酸补充剂并不能改善男性的生育能力

2020-01-08 10:40:11 CISION

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Dietary supplements containing zinc and folic acid—marketed as a treatment for male infertility—do not appear to improve pregnancy rates, sperm counts or sperm function, according to a study conducted by the Eunice Kennedy Shriver National Institute of Child Health and Human Development , part of the National Institutes of Health. The study appears in the Journal of the American Medical Association. The authors note that most so-called fertility supplements contain zinc and folic acid. Zinc is an essential mineral for sperm formation, and folate, the natural form of folic acid, depends on zinc to help form DNA in the sperm. Previous studies of these nutrients as a treatment for male infertility have produced conflicting results. In the current trial, researchers enrolled 2,370 couples planning infertility treatments in four U.S. cities and their surrounding areas. The men were assigned at random to receive either a placebo or a daily supplement containing 5 milligrams of folic acid and 30 milligrams of zinc. Live births did not differ significantly among the two groups: 404 (34%) in the supplement group and 416 (35%) in the placebo group. Similarly, the groups did not differ among various measures for sperm health, such as sperm movement, shape and total count. However, the proportion of sperm DNA fragmentation—broken DNA in the sperm—was higher in the supplement group (29.7%), compared to the placebo group (27.2%). Studies have linked a high rate of sperm DNA fragmentation to infertility. Men in the supplement group also had a higher proportion of gastrointestinal symptoms, compared to the placebo group: abdominal discomfort (6% vs. 3%), nausea (4% vs. 2%) and vomiting (3% vs. 1%). "Our study is one of the first randomized, placebo-controlled trials to assess whether folic acid and zinc supplements help to improve male fertility," said Enrique Schisterman, Ph.D., of the NICHD Division of Intramural Population Health Research, who conducted the trial, along with colleagues. "Our results suggest that these dietary supplements have little to no effect on fertility and may even cause mild gastrointestinal symptoms."  Reference Schisterman EF, et al. Effect of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: A randomized clinical trial. Journal of the American Medical Association. 2019. About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. For more information, visit http://www.nichd.nih.gov. About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov SOURCE National Institutes of Health (NIH); Eunice Kennedy Shriver National Institute of Child Health and Human Development
含有锌和叶酸的膳食补充剂,作为一种治疗男性不育的药物,似乎不能提高妊娠率、精子数量或精子功能。国家卫生研究院的一部分。这项研究发表在美国医学会杂志上。 作者指出,大多数所谓的生育补充剂含有锌和叶酸。锌是精子形成的基本矿物,叶酸是叶酸的天然形式,依靠锌帮助精子形成 DNA 。以前的研究将这些营养作为治疗男性不孕症的方法产生了相互矛盾的结果。 在目前的试验中,研究人员招募了2370对夫妇,他们计划在美国四个城市及其周边地区进行不孕症治疗。这些人被随机分配到接受安慰剂或每日补充含有5毫克叶酸和30毫克锌。 两组的活产差异不大:补充组404例(34%),安慰剂组416例(35%)。同样,这些群体对精子健康的各种措施,如精子的运动、形状和总数也没有不同。然而,与安慰剂组(27.2%)相比,补充剂组(29.7%)精子 DNA 碎裂的比例更高。研究已经将精子 DNA 的高度碎片率与不孕症联系起来. 与安慰剂组相比,补充剂组男性胃肠道症状的比例更高:腹部不适(6% vs3%)、恶心(4% vs2%)和呕吐(3% vs1%)。 “我们的研究是第一个随机,安慰剂控制的试验,以评估叶酸和锌补充剂是否有助于提高男性的生育能力,”恩里克 Schisterman 博士, NICHD 部门的内部人口健康研究,谁进行了试验,与同事。“我们的结果表明,这些膳食补充剂对生育能力几乎没有影响,甚至可能导致轻度胃肠道症状。” 参考资料 Schisterman EF 等。叶酸和锌补充对不孕夫妇精液质量和活产的影响:随机临床试验。美国医学会杂志.2019年。 关于 Eunice Kennedy Shriver 国家儿童健康和人类发展研究所( NICHD ): NICHD 领导研究和培训,以了解人类发展,改善生殖健康,提高儿童和青少年的生活,并优化所有人的能力。详情请访问 http://www.nichd.nih.gov 。 关于美国国立卫生研究院( NIH ): NIH ,国家医学研究机构,包括27个研究所和中心,是美国卫生和人类服务部的一个组成部分。NIH 是负责和支持基础医学、临床医学和转化医学研究的主要联邦机构,正在调查常见和罕见疾病的病因、治疗和治疗方法。有关 NIH 及其计划的更多信息,请访问 http://www.nih.gov 国立卫生研究院; EuniceKennedy Shriver 国家儿童健康和人类发展研究所

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