Could Cannabis Beat Big Pharma to a Cure for Alzheimer's?

大麻能打败大制药公司,成为治疗老年痴呆症的药物吗?

2021-01-14 00:00:00 Cannabis

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The growth of medical marijuana has seen a huge rise in beneficial researches into the use of the medicinal herb. These researches are serving as the basis for which the public is getting to accept marijuana as a medicinal herb. Cannabis has been found to be effective in dealing with pain, inflammation, and seizures through the work of its cannabinoids. One medical application where medical marijuana researchers are placing much emphasis on is in the area of Alzheimer’s disease. Could cannabis beat big pharma to an Alzheimer’s cure, let’s see what the research says. Alzheimer’s disease Alzheimer’s disease is a progressive neurological disorder that involves the shrinking of brain cells and ultimately leads to the death of the cells. This death of brain cells tends to cause dementia in such patients. Such patients suffer from a reduction in thinking ability and their behavioral and social skills begin to diminish. The US population has 5.8 million people that are over 65 suffering from Alzheimer’s and 80% of these people are aged 75 and above. Another staggering statistic is that among 50 million people suffering from dementia worldwide, about 70% have Alzheimer’s disease. The symptoms of Alzheimer’s disease majorly applies to memory loss. Patients suffering from Alzheimer’s tend to have difficulty remembering recent events. This eventually leads to memory impairment and difficulty with thinking and reasoning. Patients also suffer from changes in personality and behavior which promotes mood swings and social withdrawal. The major cause of Alzheimer’s disease is not well understood. The process of degeneration occurs long before the symptoms start to occur in the patients which makes it hard. To determine when it starts. Researches show that plaques are to blame for the development of toxic material in the brain. There is presently no cure for Alzheimer’s disease and big pharma are working endlessly to find a breakthrough. The major measures adopted right now are to limit the risk factors that can be modulated such as air pollution, alcohol use, poor sleep, and cognitive impairment. The use of cannabis is actively being researched for effectiveness in dealing with Alzheimer’s disease and its symptoms. Some of those researches are showing early signs of positivity. What does the researchers say? Many of the people currently suffering from Alzheimer’s disease lived in an era when reefer madness marketing campaigns were ripe. The war on drugs made it hard for most to associate with cannabis but current studies show that the use of cannabis might have helped in reducing the progress of Alzheimer’s disease. Studies done on mice show that CBD doses and a combination of CBD and THC doses have the chance of helping to deal with Alzheimer’s. The doses of the cannabinoids target the main issue that causes dementia and Alzheimer’s disease in the brain. A buildup of beta-amyloid plaques is known to create inflammation that promotes Alzheimer’s disease in the brain. Studies have shown that CBD has the ability to reduce the plaque's effect of causing inflammation in the brain. This reduces the toxic effects of the plaque in the brain and reduces the progression of dementia and Alzheimer’s disease. Other studies also show the effectiveness of CBD in reducing the concentration of A-beta plaques in the brain over time. This points to the fact that early usage of cannabis could be effective in reducing the onset of Alzheimer’s disease. Although this is not yet backed up scientifically, but hypothetically speaking the stats are there. This means that those suffering from Alzheimer’s diseases could have benefited if marijuana was not criminalized during the war on drugs era. Still on the works of research Dr. Ethan Russo is a neuroscientist and the director of Research and Development at the International Cannabis and Cannabinoids Institute. Dr. Ethan has been working extensively on the effects of cannabis and cannabinoids on Alzheimer’s disease. His research is also based on THC and CBD being effective to interfere with the production of toxic materials in patient’s brains. He is confident that the study should be taken into the clinical phase where it’s effectiveness can be some with clinical studies. This move will be a step further than big pharma has gotten in recent years with cannabis. Most of the synthetic drugs available by big pharmaceutical companies are yet to reach the clinical stage. Most are directed towards attending to the underlying symptoms of cannabis such as memory impairment and sleep disturbance. This shows the possibility of cannabis beating big pharma to getting a cure for Alzheimer’s if researchers like Dr. Ethan get to go forward with their research. THC and CBD are known to have a neuroprotective activity that can help to slow down the degenerative process. Dr. Russo explains that THC on its own is effective in dealing with night agitation. This action is also present in CBD as it helps to get rid of sleep disturbances. This means that both cannabinoids are effective in promoting sleep and improving the quality of life of the patients. These are some of the major aspects of the life of patients of Alzheimer’s that are greatly affected. The FDA has approved the use of some pharmaceutical drugs to treat memory loss in Alzheimer’s disease patients. These drugs have mild benefits as they offer temporary effects to remedy memory loss in such patients. The drugs work by increasing the amount of acetylcholine in the brain which helps to improve the storage of information. This activity is also present in a terpene in cannabis. Alpha-pinene is a terpenoid in cannabis that boosts acetylcholine concentration by inhibiting its breakdown. It does this with fewer side effects which makes cannabis more beneficial for treating the symptoms as opposed to synthetic drugs. Bottom line Though the works of research are gathering pace, we are still a long way from significant clinical studies of cannabis for Alzheimer’s disease. When that eventually happens, there are chances that medical marijuana can beat big pharma to the elusive cure for Alzheimer’s disease. A PUFF A DAY TO KEEP ALZHEIMER'S AWAY, READ WHAT DOCTOR SAY! CBD FIGHTS THE IRON BUILD UP LEADING TO ALZHEIMER'S!
医用大麻的增长已经看到了对药用草药使用的有益研究的巨大增长。这些研究正在成为公众接受大麻作为一种草药的基础。大麻通过其大麻素的作用被发现在治疗疼痛,发炎和癫痫方面是有效的。医用大麻研究者非常重视的一个医疗应用是阿尔茨海默氏症。 大麻是否能击败大制药公司,成为治疗老年痴呆症的良药,让我们来看看研究结果。 阿尔茨海默病 阿尔茨海默病是一种进行性的神经紊乱,涉及脑细胞的萎缩,最终导致细胞的死亡。这种脑细胞的死亡倾向于导致这类患者的痴呆。这类患者的思维能力下降,行为和社交能力开始减退。美国人口中有580万65岁以上的人患有老年痴呆症,其中80%的人年龄在75岁及以上。另一个令人咋舌的统计数据是,在全球5000万患有痴呆症的人中,约有70%的人患有阿尔茨海默病。 老年痴呆症的症状主要表现为记忆力减退。患有老年痴呆症的病人往往难以记住最近发生的事情。这最终导致记忆力受损,思维和推理困难。患者还会因性格和行为的改变而感到痛苦,这会导致情绪波动和社交退缩。阿尔茨海默氏病的主要原因还不是很清楚。退行性变的过程在患者症状开始出现之前很久就发生了,这使其变得困难。以确定它何时开始。研究表明,脑内有毒物质的形成应归咎于斑块。 阿尔茨海默氏病目前还没有治愈方法,大制药公司正没完没了地寻找突破口。目前采取的主要措施是限制可调节的风险因素,如空气污染,酗酒,睡眠不良和认知障碍。目前正在积极研究大麻的使用对治疗阿尔茨海默病及其症状的有效性。其中一些研究显示出了积极的早期迹象。 研究人员怎么说? 许多目前患有阿尔茨海默氏症的人生活在冷藏箱疯狂营销活动成熟的时代。禁毒战争使大多数人很难将大麻与之联系在一起,但目前的研究表明,大麻的使用可能有助于减少老年痴呆症的进展。在老鼠身上做的研究表明,CBD剂量以及CBD和THC的联合剂量有可能帮助治疗老年痴呆症。大麻素的剂量针对导致大脑痴呆和阿尔茨海默病的主要问题。 已知Beta-淀粉样蛋白斑块的积累会引起炎症,从而促进大脑中的阿尔茨海默氏病(Alzheimers disease,阿尔茨海默氏症)。研究表明,CBD有能力降低在大脑中引起炎症的斑块效应。这就减少了大脑中斑块的毒性作用,减少了痴呆和阿尔茨海默病的进展。其他研究也显示CBD随着时间的推移降低大脑中A-beta斑块浓度的有效性。这表明,早期使用大麻可以有效地减少阿尔茨海默病的发病。虽然这还没有得到科学上的支持,但假设性地说,统计数据是存在的。这意味着,如果在禁毒战争时代大麻不被定罪,那些患有老年痴呆症的人本可以从中受益。 仍在研究工作中 伊森罗素博士是一位神经科学家,也是国际大麻和大麻素研究所的研究和发展主任。伊森博士一直在研究大麻和大麻素对老年痴呆症的影响。他的研究还基于THC和CBD能有效地干扰病人大脑中有毒物质的产生。他相信这项研究应该进入临床阶段,在临床研究中ITS的有效性可以达到一定程度。 这一举措将比大型制药公司近年来在大麻方面取得的进展更进一步。大型制药公司现有的大部分合成药物尚未达到临床阶段。大多数是针对大麻的潜在症状,如记忆障碍和睡眠障碍。这表明,如果像伊森博士这样的研究人员能够继续他们的研究,大麻有可能击败大制药公司获得治疗老年痴呆症的方法。 已知THC和CBD具有神经保护活性,可以帮助减缓退行性变过程。罗素博士解释说,THC本身在处理夜间躁动方面是有效的。这种作用也存在于CBD,因为它有助于摆脱睡眠障碍。这意味着这两种大麻素在促进睡眠和改善患者生活质量方面都是有效的。这些都是阿尔茨海默病患者生活中受到很大影响的一些主要方面。 FDA已经批准使用一些药物来治疗老年痴呆症患者的记忆丧失。这些药物有轻微的好处,因为它们提供暂时的效果,以补救这类患者的记忆丧失。这些药物通过增加大脑中乙酰胆碱的数量而起作用,而乙酰胆碱有助于改善信息的储存。这种活性也存在于大麻中的一种萜烯中。Alpha-pinene是大麻中的一种萜类化合物,通过抑制乙酰胆碱的分解来提高乙酰胆碱的浓度。这样做的副作用更少,这使得大麻比合成药物更有利于治疗症状。 底线 尽管研究工作的步伐正在加快,但我们离大麻治疗阿尔茨海默病的重要临床研究还有很长的路要走。当这种情况最终发生时,医用大麻就有可能击败大型制药公司,成为阿尔茨海默氏症难以捉摸的治疗方法。 每天吸一口,远离老年痴呆症,看看医生怎么说! CBD对抗导致阿尔茨海默氏症的铁积累!

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