Could Cannabis Heighten a Protein's Ability to Fight Viruses and Inflammation?

大麻能提高蛋白质对抗病毒和炎症的能力吗?

2021-01-15 00:00:00 Cannabis

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The year 2020 was largely dominated by the events of the COVID-19 pandemic. This has driven many cannabis companies to make different claims about the effectiveness of cannabis in helping to deal with viral infections. Cannabis is already known to be a natural herb with numerous medicinal applications so it is important to know the true scope of these claims. This article will shed light on the role of marijuana with viral infections and the possibility of cannabis heightening a protein’s ability to fight viruses and inflammation.  Cannabis and inflammation Cannabis has a very unique relationship with the immune system of the body. There are numerous components in the full spectrum plant matrix of cannabis. CBD is one of the cannabinoids present in the matrix and research has shown the relationship between CBD and the immune system. By indirectly acting through the endocannabinoid system, CBD helps to regulate the immune system. Through this activity of regulating the immune system, CBD reduces the inflammatory response. This is the concept of the use of CBD for dealing with muscle inflammation and other inflammatory diseases such as arthritis. The immune system is very complex and plays host to different organs and cell types that help to fight foreign molecules. The skin acts as a physical barrier to keep such foreign agents away but when they make their way into the system, the immune system deals with them. When a virus makes its way into the body system, the immune system has special antibodies that attack this viral agent. This special activity by the immune system and the special relationship CBD has with the immune system has been purported for the anti-viral activity of cannabis. However, there are no sufficient studies yet to validate the antiviral activity of cannabis. The body produces special endocannabinoids such as anandamide and 2-Arachidonyl Glycerol. The endocannabinoid system was initially thought to contain two receptors majorly CB1 and CB2. However, research has shown that the system consists of over 50 enzymes, receptors, and endocannabinoids. These endocannabinoids and the cannabinoids in cannabis work directly and indirectly to affect the immune system. This is the basis for the topical creams and transdermal patches used for pain relief and to deal with inflammation. Special protein that fights viruses and proteins Researchers in different centers are looking into the effectiveness of a special protein with a unique ability to fight viruses and inflammation. This special protein is known as ZBP1 and researchers from far and wide are already working on it. Some of the top centers working on this protein include the Cluster of Excellence in Aging Research of the University of Cologne, the University of Texas Health Science Center, and the Francis Crick Institute in London. ZBP1 is a unique protein that has a special ability to defend against viruses. The protein is activated when it senses Z-nucleic acids which is an unusual form of genetic material. The activation of this protein leads to the death of cells and inflammation. Z-nucleic acid is a special cellular genetic material with double-stranded DAN and RBA molecules. It also has a special left-handed double helix structure. The protein has been discovered over 40 years ago and since then, scientists have been working to explore its potential. The protein upon activation senses the genetic makeup of the virus and after identifying the threat, it activates a kill-sequence. This is somewhat similar to the activity of some of the killer cells in the immune system against such foreign invaders. The protein also activates this special kill-sequence when it senses RIPK1. RIPK1 is a special protein that stops the activity of ZBP1. This activity of ZBP1 also applies to the immune system and the regulation of inflammation. This is why it is also being researched for inflammatory diseases such as arthritis. Different studies have been put forward to fully understand this protein. Professor Manolis Pasparakis is one of the lead scientists in a study on ZBP1. Using mouse models to elicit the action of the protein, it has been identified that the protein binds to double-stranded RNA. This binding action of the protein helps it in the regulation of the immune system and inflammation. Can cannabis heighten ZBP1?  The search into the complementary action of cannabis with ZBPI was birthed based on the similarity in their actions. The existence of such activity will help open up another mode of the effectiveness of cannabis and CBD against inflammation. It will also help to provide positive headway for alternative therapies for dealing with inflammatory diseases such as arthritis. With the similarities in their activities, some studies are confidently looking into the use of cannabis to heighten the activity of ZBP1. In vivo and in vitro studies already show the activity of CBD  in the regulation of the immune system. Scientists are looking into the possibility of this activity of CBD contributing to that of ZBP1. It will serve as the basis for novel therapies for diseases involving viral infections and inflammation. Although, it is still very early to say, early signs point to the effectiveness of cannabis to heighten ZBP1. Both have similar effects, chances are that the use of cannabis will offer synergistic action. Scientists are already looking into ways to solidify the effects of THC on the body and its genomes. This protein offers a chance to fully study that and offer a new therapy model heading into the future. Bottom line The uniqueness of ZBP1 and its activity makes it a gem in the medical world. It is not a matter of IF but a matter of WHEN scientists utilize it for the betterment of health. With a combination of cannabis and the beneficial cannabinoids, ZBP1 can be a huge benefit in the fight against viruses and inflammatory diseases. Although there is still a need for more clinical researches to be carried out on the protein; early indications show promise which is why scientists are pressing on. CAN CANNABIS HELP FIGHT THE BODY FIGHT COVID-19?
2020年主要是COVID-19大流行。这驱使许多大麻公司对大麻在帮助对付病毒感染方面的有效性提出了不同的主张。人们已经知道大麻是一种具有多种药用用途的天然草药,因此了解这些声称的真正范围是很重要的。这篇文章将阐明大麻与病毒感染的作用,以及大麻提高一种蛋白质对抗病毒和炎症的能力的可能性。 大麻与炎症 大麻与身体的免疫系统有着非常独特的关系。大麻的全谱植物基质中有许多成分。CBD是基质中存在的大麻素之一,研究表明CBD与免疫系统之间的关系。通过间接作用于内源性大麻素系统,CBD有助于调节免疫系统。通过这种调节免疫系统的活动,CBD降低了炎症反应。这就是CBD用于治疗肌肉炎症和其他炎症性疾病如关节炎的概念。 免疫系统是非常复杂的,并且扮演着不同器官和细胞类型的宿主,这些器官和细胞类型有助于对抗外来分子。皮肤起着物理屏障的作用,将这些外来物质拒之门外,但当它们进入系统时,免疫系统就会处理它们。当病毒进入人体系统时,免疫系统会产生特殊的抗体来攻击这种病毒。免疫系统的这种特殊活性以及生物多样性与免疫系统的特殊关系被认为是大麻抗病毒活性的原因。然而,还没有充分的研究证实大麻的抗病毒活性。 人体产生特殊的内源性大麻素,如阿南德酰胺和2-花生四烯酰甘油。最初认为内源性大麻素系统含有两种受体,主要为CB1和CB2。然而,研究表明,该系统由50多种酶,受体和内源性大麻素组成。这些内源性大麻素和大麻中的大麻素直接或间接影响免疫系统。这是用于止痛和处理炎症的外用面霜和透皮贴片的基础。 对抗病毒和蛋白质的特殊蛋白质 不同中心的研究人员正在研究一种特殊蛋白质的有效性,这种蛋白质具有独特的对抗病毒和炎症的能力。这种特殊的蛋白质被称为ZBP1,来自世界各地的研究人员已经在研究它。研究这种蛋白质的一些顶尖中心包括科隆大学的衰老研究卓越中心,德克萨斯大学健康科学中心和伦敦的弗朗西斯克里克研究所(Francis Crick Institute)。 ZBP1是一种独特的蛋白质,具有特殊的抗病毒能力。这种蛋白质在感觉到Z-核酸时被激活,而Z-核酸是一种不寻常的遗传物质形式。这种蛋白的激活导致细胞死亡和炎症。Z-核酸是一种特殊的细胞遗传物质,具有双链DAN和RBA分子。它还具有特殊的左撇子双螺旋结构。 这种蛋白质在40多年前就被发现了,从那时起,科学家们就一直在探索它的潜力。该蛋白在激活后会感觉到病毒的基因组成,在识别出威胁后,它会激活一个杀灭序列。这有点类似于免疫系统中的一些杀伤细胞对抗这类外来入侵者的活动。当该蛋白感知到RIPK1时,也会激活这种特殊的杀灭序列。RIPK1是一种阻止ZBP1活性的特殊蛋白。 ZBP1的这种活性也适用于免疫系统和炎症的调节。这就是为什么它也被研究用于炎症疾病,如关节炎。人们提出了不同的研究来充分了解这种蛋白质。Manolis Pasparakis教授是ZBP1研究的主要科学家之一。利用小鼠模型来诱导该蛋白的作用,已经鉴定出该蛋白与双链RNA结合。蛋白质的这种结合作用有助于调节免疫系统和炎症。 大麻能升高ZBP1吗? 研究大麻与ZBPI的互补作用是基于二者作用的相似性而产生的。这种活动的存在将有助于开辟大麻和生物多样性公约抗炎效力的另一种模式。它还将有助于为治疗关节炎等炎症疾病的替代疗法提供积极的进展。 由于它们的活动有相似之处,一些研究正满怀信心地探讨使用大麻来提高ZBP1的活动。体内和体外研究已经显示CBD在调节免疫系统中的活性。科学家们正在研究CBD的这一活性是否有助于ZBP1的活性。它将成为治疗涉及病毒感染和炎症的疾病的新疗法的基础。 虽然现在说还为时尚早,但早期迹象表明大麻能有效地提高ZBP1。两者都有类似的效果,大麻的使用可能会产生协同作用。科学家们已经在寻找方法来巩固THC对人体及其基因组的影响。这种蛋白质提供了一个全面研究的机会,并提供了一个新的治疗模式,走向未来。 底线 ZBP1的独特性及其活性使其成为医学界的一颗宝石。这不是一个是否的问题,而是科学家何时利用它来改善健康的问题。结合大麻和有益的大麻素,ZBP1可以在对抗病毒和炎症疾病中发挥巨大的作用。虽然该蛋白仍需进行更多的临床研究;早期的迹象显示有希望,这就是为什么科学家们正在加紧研究的原因。 大麻能帮助对抗身体对抗Covid-19吗?

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