Cannabis and Antidepressants - Can You Mix Them Together or Better Not?

大麻和抗抑郁药--你能把它们混在一起还是最好别混在一起?

2021-01-26 01:05:26 Cannabis

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Cannabis has been loved for centuries by its users for the different types of effects it offers. Some cannabis enthusiasts have gone further by trying different means to augment these effects. Some for medical reasons, while some are exploring the possibility just for recreational  purposes. While these combinations can really open users up to a different dimension of effects, it is important that care is taken while combining cannabis with other drugs. One such class of drugs that has been mixed with cannabis for desired effects are antidepressants. Read on as we look deeply into what occurs when cannabis is mixed with antidepressants. Cannabis and Antidepressants Antidepressants are a special class of prescription drugs that are used to help elevate the moods of people suffering from depression. An analysis by the American Psychological Association shows that 8 percent of people between the age of 20 to 39 are on antidepressant medication. There are different classes of antidepressants that work by different mechanisms. Examples of the classes include Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), Tricyclic Antidepressants (TCA), and Monoamine Oxidase Inhibitors (MAO). Over 260 million people worldwide suffer from depression and many rely on these drugs for relief from its symptoms. Cannabis has also be termed to be effective for dealing with depression. The natural herb contains cannabinoids such as THC and CBD which can help with mood elevation and promoting calm and relaxation. The ability of these cannabinoids to create euphoric feeling has been projected by many as a therapeutic answer to the symptoms of depression. Though there are limited clinical evidence to support this fact, however, anecdotal evidence point to its effectiveness. This reality has prompted the reality of patients on antidepressants combining the prescribed drugs with cannabis for better effectiveness. The question we should ask is what exactly occurs when cannabis is mixed with antidepressants. Does it augment the effects of the antidepressants to treat the depression in synergy? Does it antagonize the effect of the antidepressants and reduce their therapeutic effectiveness. Read on as we provide answers to these questions. Synergistic effect of Cannabis and Antidepressants The general idea of using cannabis and antidepressants is to bring about synergistic action between the drugs. Though there are limited studies on the topics, early signs show the possibility of this effect. Cannabis works in the body through the endocannabinoid system which has a huge role to play in the regulation of mood in the body. The endocannabinoid system contains special cannabinoid receptors, endocannabinoids, and enzymes that work to modulate the system. Different cannabinoids from cannabis work through this system to help promote elevated moods and relaxation. Some of the cannabinoids in cannabis also have structures similar to endocannabinoids in the system. This helps them to directly or indirectly affect the system. THC for example promotes elevated mood with a euphoric feeling while CBD gives rise to relaxed states. These effects of cannabis along with anecdotal evidence promote the proposed effectiveness of cannabis for depression. This has prompted research into the synergistic role of cannabis with antidepressants. Danielle Romell Ph.D., a Director at the University of California, Irvine worked to show this effect in a particular study. While operating under the Centre for Study of Cannabis at the university, she researched if adding cannabis to 10mg or 20mg of Prozac or Paxil makes it more effective. The issue she was able to identify with the study was the dose of cannabis. For marijuana users that self medicate, they do not work with a particular dose making it hard to arrive at a definite conclusion of effectiveness. Using a dose that is too small can bring no therapeutic effect. Likewise using a dose that is too high can bring about other health risks. This is why if cannabis users on antidepressants are going to use cannabis with it, it is advisable to start slow and work your way up. Expected effects when it comes to cannabis varies in terms of varieties of strain and quantity. While starting, it is best to use a strain with a balanced cannabinoid profile in terms of the ratio of THC and CBD. This will help to promote reproducibility of the effects experienced. Relationship between cannabis and different classes of antidepressants As stated earlier, there are different classes of antidepressants, and cannabis and its cannabinoids interact differently with these antidepressants. The antidepressants have different mechanisms of action which means that it can have a different types of interactions with the effects of cannabis. Cannabis can interfere with the metabolism of the drug thereby making it more available. This increases the potency of the drug because more of the drug is available in the system. Cannabis can also reduce the effectiveness of the drug by increasing the rate of excretion Selective Serotonin Reuptake Inhibitors (SSRIs) ex. Prozac, Paxil CBD increases the potency of SSRIs by reducing the rate of its excretion. This makes the antidepressant concentration in the body to be increased to bring about a therapeutic effect. SSRIs also have a low risk of potential side effects when combined with CBD. However, it is important to note that excess serotonin creates a condition known as Serotonin syndrome. Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) ex. Cymbalta, Fetzima THC reduces the effectiveness of this class of antidepressants because it increases its rate of excretion. This class of antidepressants has a low to moderate risk of potential side effects. Tricyclic Antidepressants (TCA) ex. Imipramine, Amitriptyline. This class of antidepressants has a high risk of potential side effects with cannabis. Side effects include dry mouth, high blood pressure, and constipation. It is advised that such a class of antidepressants is not to be mixed with cannabis. Monoamine Oxidase Inhibitors (MOIs) ex. Phenelzine This class of antidepressants has a high risk of potential side effects when combined with cannabis. Side effects can include fatigue, muscle aches, insomnia, and reduced libido. It is advised that this class of antidepressants is not to be mixed with cannabis. Bottom line Cannabis can be mixed with antidepressants but care has to be taken to avoid unwanted side effects. Ensure you talk to a health professional before mixing cannabis and antidepressants. ARE YOUR ANTIDEPRESSANTS KILLING YOU SLOWLY? CANNABIS AND THE NATURAL ANTIDEPRESSANT IN YOUR BODY!
几个世纪以来,大麻因其具有不同类型的功效而受到使用者的喜爱。一些大麻爱好者更进一步,试图用不同的方法来增强这些效果。有些是出于医疗原因,有些则只是为了娱乐目的而在探索这种可能性。虽然这些组合确实会使使用者受到不同层面的影响,但在将大麻与其他药物组合时必须谨慎从事。为了达到预期效果,与大麻混合使用的一类药物是抗抑郁药。让我们继续深入研究当大麻与抗抑郁药混合时会发生什么。 大麻和抗抑郁药 抗抑郁药是一类特殊的处方药,用来帮助抑郁症患者改善情绪。美国心理学会的一项分析显示,在20到39岁之间的人群中,有8%的人在服用抗抑郁药物。有不同种类的抗抑郁药通过不同的机制起作用。这些类别的例子包括选择性5-羟色胺再摄取抑制剂(SSRIs),5-羟色胺去甲肾上腺素再摄取抑制剂(SNRIs),三环抗抑郁药(TCA)和单胺氧化酶抑制剂(MAO)。全世界有超过2.6亿人患有抑郁症,许多人依赖这些药物来缓解症状。 大麻也被认为是治疗抑郁症的有效药物。这种天然草本含有大麻素,如THC和CBD,可以帮助情绪提升,促进平静和放松。这些大麻素产生快感的能力被许多人认为是抑郁症症状的一种治疗方法。虽然有有限的临床证据支持这一事实,然而,轶事证据指出其有效性。这一现实促使抗抑郁药患者将处方药物与大麻相结合以获得更好效果的现实。 我们应该问的问题是,当大麻与抗抑郁药混合时,究竟发生了什么。它是否增强了抗抑郁药协同治疗抑郁症的效果?它是否拮抗了抗抑郁药的作用,降低了它们的治疗效果。请继续阅读我们为这些问题提供的答案。 大麻与抗抑郁药的协同作用 使用大麻和抗抑郁药的一般想法是使药物之间产生协同作用。虽然目前对这一主题的研究还很有限,但早期的迹象表明了这一效应的可能性。大麻通过内源性大麻素系统在体内发挥作用,内源性大麻素系统在调节体内情绪方面发挥着巨大的作用。内源性大麻素系统包含特殊的大麻素受体,内源性大麻素,以及调节系统的酶。来自大麻的不同大麻素通过这个系统来帮助提升情绪和放松。 大麻中的一些大麻素也具有类似于系统中内源性大麻素的结构。这有助于他们直接或间接地影响系统。例如,THC以欣快的感觉提升情绪,而CBD则带来放松的状态。大麻的这些作用,连同轶事证据,促进了大麻治疗抑郁症的拟议有效性。 这促使人们研究大麻与抗抑郁药的协同作用。加州大学欧文分校的主任Danielle Romell博士在一项特殊的研究中展示了这种效应。在大学大麻研究中心工作期间,她研究了在10mg或20mg百忧解或帕罗西汀中加入大麻是否会更有效。她在研究中发现的问题是大麻的剂量。对于自行用药的大麻使用者来说,他们并不使用特定的剂量,因此很难得出确切的有效性结论。使用太小的剂量不能带来治疗效果。同样,使用过高的剂量会带来其他健康风险。 这就是为什么如果服用抗抑郁药的大麻使用者在服用大麻的同时,最好先慢慢来,慢慢地往上爬。大麻的预期效果因品种和数量的不同而不同。当开始时,最好使用一种在THC和CBD的比例方面具有平衡大麻素轮廓的菌株。这将有助于促进所经历的效果的重现性。 大麻与不同类型抗抑郁药的关系 如前所述,有不同类别的抗抑郁药,大麻及其大麻素与这些抗抑郁药的相互作用也不同。抗抑郁药有不同的作用机制,这意味着它可以与大麻的作用有不同类型的相互作用。大麻会干扰药物的新陈代谢,从而使其更容易获得。这增加了药物的效力,因为更多的药物在系统中可用。大麻也会通过增加排泄率而降低药物的效力 选择性5-羟色胺再摄取抑制剂。百忧解,帕罗西汀 CBD通过降低SSRIs的排泄率而提高SSRIs的效力。这使得体内的抗抑郁药浓度增加,从而产生治疗效果。SSRIs与CBD合用时潜在副作用的风险也很低。然而,需要注意的是,过量的血清素会造成一种称为血清素综合征的状况。 5-羟色胺和去甲肾上腺素再摄取抑制剂。费齐马·辛巴尔塔 THC降低了这类抗抑郁药的有效性,因为它增加了排泄率。这类抗抑郁药具有低至中度的潜在副作用风险。 三环类抗抑郁药。丙咪嗪,阿米替林。 这类抗抑郁药与大麻有很高的潜在副作用风险。副作用包括口干,高血压和便秘。建议不要将这类抗抑郁药与大麻混合使用。 单胺氧化酶抑制剂等。苯乙肼 这类抗抑郁药与大麻合用时有很高的潜在副作用风险。副作用包括疲劳,肌肉疼痛,失眠和性欲减退。建议不要将这类抗抑郁药与大麻混用。 底线 大麻可以与抗抑郁药混合使用,但必须注意避免不想要的副作用。在混合使用大麻和抗抑郁药之前,确保你与健康专业人士交谈。 你的抗抑郁药在慢慢杀死你吗? 大麻和你体内的天然抗抑郁药!

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