THC-Rich Cannabis Oil Could Be Effective Autism Treatment

富含四氢大麻酚的大麻油可有效治疗自闭症

2022-01-04 03:30:10 Ganjapreneur

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Researchers at Tel Aviv University alleviated autism symptoms in animal models using medical cannabis oil, according to a study published in the journal Translational Psychiatry outlined by Israel 21c. Shani Poleg, the Ph.D. candidate who led the research, said the team found that cannabis oil had “a favorable effect on compulsive and anxious behaviors in model animals.” “According to the prevailing theory, autism involves overarousal of the brain, which causes compulsive behavior. In the lab, in addition to the behavioral results, we saw a significant decrease in the concentration of the arousing neurotransmitter glutamate in the spinal fluid — which can explain the reduction in behavioral symptoms.” — Poleg to Israel21c The researchers found that CBD treatment alone had no impact on the behavior of the animal models, while THC-rich cannabis oil produced “equal or even better behavioral and biochemical effects.” “We observed significant improvement in behavioral tests following treatments with cannabis oil containing small amounts of THC,” Poleg said in the interview, “and observed no long-term effects in cognitive or emotional tests conducted a month and a half after the treatment began.” The study authors note that treating children with autism spectrum disorder using cannabis products “raises medical and ethical questions” since many patients are young children. “During young childhood and adolescence, multiple neurological systems, such as the glutamatergic, dopaminergic and endocannabinoid systems, rearrange and maturate,” the authors write. “Data show that some cannabinoids, THC among them, might harm the developing brain.” The authors said the study results “question the necessity of high doses of CBD in medical cannabis oils designated for alleviating [autism spectrum disorder] core symptoms, and suggest that a medical cannabis oil that contains relatively small doses of THC is preferable, due to an additional plausible effect on social behavior.” A separate study conducted by researchers at Israel’s Ben-Gurion University of the Negev and Soroka University Medical Center published last year found more than 80% of parents of autistic children reported significant or moderate improvement in their child while using CBD-rich cannabis oils. Get daily news insights in your inbox. Subscribe End Authored By: TG joined Ganjapreneur in 2014 as a news writer and began hosting the Ganjapreneur podcast in 2016. He is based in upstate New York, where he also teaches media studies at a local university.
根据以色列21C概述的发表在《翻译精神病学》杂志上的一项研究,特拉维夫大学的研究人员使用医用大麻油减轻了动物模型中的自闭症症状。Shani Poleg,博士领导这项研究的候选人说,研究小组发现大麻油“对模型动物的强迫和焦虑行为有有利影响”。 “根据流行的理论,自闭症涉及大脑过度唤醒,从而导致强迫行为。在实验室里,除了行为方面的结果,我们还看到脊髓液中引起兴奋的神经递质谷氨酸的浓度显著降低--这可以解释行为症状的减少。“-Poleg to Israel21c 研究人员发现,CBD单独治疗对动物模型的行为没有影响,而富含四氢大麻酚的大麻油产生了“同等甚至更好的行为和生化效果”。 “我们观察到,在使用含有少量四氢大麻酚的大麻油治疗后,行为测试有了显著改善,”Poleg在采访中说,“在治疗开始一个半月后进行的认知或情绪测试中,没有观察到长期影响。” 研究作者指出,使用大麻产品治疗自闭症谱系障碍儿童“提出了医学和伦理问题”,因为许多患者是幼儿。 作者写道:“在幼年和青春期,多种神经系统,如谷氨酸能、多巴胺能和内源性大麻素系统,重新排列和成熟。”“数据显示,一些大麻素,其中包括四氢大麻酚,可能会伤害发育中的大脑.” 作者表示,研究结果“质疑用于缓解(自闭症谱系障碍)核心症状的医用大麻油中高剂量CBD的必要性,并建议含有相对小剂量四氢大麻酚的医用大麻油更可取,因为它对社会行为有额外的可信影响。” 以色列内盖夫本-古里安大学和索罗卡大学医学中心的研究人员去年发表的一项单独研究发现,超过80%的自闭症儿童父母报告说,在使用富含CBD的大麻油时,他们的孩子有了显著或中度的改善。 在收件箱中获取每日新闻见解。订阅 结束 作者: TG于2014年加入Ganjapreneur担任新闻作家,并于2016年开始主持Ganjapreneur播客。他住在纽约州北部,在当地的一所大学教授媒体研究。

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